DIAGNOSTIC APPROACHES TO QUASIDEPRESSIVE MANIFESTATIONS IN POOL OF NEGATIVE SYMPTOMS IN PATIENTS WITH RESIDUAL SCHIZOPHRENIA
Relevance. In modern mental disorders systematics, post-schizophrenic depression was finally integrated into the context of schizophrenia, thus creating a position for the analysis of depressive manifestations role in the structure of the schizophrenic defect.
The aim of the study: to develop approaches to the analysis of manifestations of the depressive spectrum in patients with residual schizophrenia, with pronounced negative symptoms.
Materials and methods. A study of 92 patients of the Zaporizhzhya Regional Clinical Psychiatric Hospital with a diagnosis of residual schizophrenia was conducted; the research methods are the evaluation of clinical data according to the criteria and diagnostic categories of “The Positive and Negative Syndrome Scale (PANSS)” and “Hamilton Depression Rating Scale” (HRDS), followed by analysis of the strength of the correlation using Spearman’s rank correlation coefficient.
Study results. An approach to the analysis of affective manifestations of the depressive spectrum in the studied contingent was developed by theoretical comparison of PANSS and HRDS criteria. The analysis is based on the hypothesis regarding the possibility of using the HRDS criteria, which have weak or negative indicators of the strength of correlation with the PSS and NSS criteria in the PANSS (used to assess the main complex of schizophrenia symptoms). The principles of selection of criteria in the pool of valid ones are accepted: if the criterion is similar to the PSS and NSS criteria, the strength of correlation should be less than noticeable; if the criterion is similar to GPS criteria, the strength of correlation should be more than noticeable; if the criterion corresponds to the previous items, or has no analogues in the PANSS, there should be no factors masking the criterion.
Conclusions. The analysis of the strength of the correlation between the HRDS depression criteria and the criteria available in the PANSS reveals the following symptoms as promising for the diagnosis of the manifestation of symptoms of the depressive spectrum in patients with residual schizophrenia: low mood, psychomotor inhibition and insomnia. These criteria can be considered promising if there are no changes in therapy in the period of 2 weeks before the assessment of the condition; phases of exacerbation of the residual complex of symptoms; violations of patient care, including maintenance of sleep, activity, nutrition; the presence of comorbid physical health disorders that can cause general somatic and autonomic symptoms.
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