IMMUNOGENETIC ASPECTS OF DISEASE PATHOGENESIS IN CHILDREN WITH AUTISM SPECTRUM DISORDERS

  • Дмитро Валерійович Мальцев Candidate of Sciences in Medicine, associate professor, head of the laboratory of immunology and molecular biology Experimental and Clinical Medicine Institute at the O.O. Bogomolets National Medical University
  • Ніна Володимирівна Коляденко PhD, Associate Professor, Head of the Department of Medical Psychology of the Institute of Medical and Pharmaceutical Sciences, PJSC “Interregional Academy of Personnel Management”
Keywords: autoantibodies, proinflammatory cytokines, neurotropic infections, folate cycle deficiency, immunotherapy.

Abstract

The article reviews the latest advances in understanding the immunopathogenesis of autism spectrum disorders and other common neuropsychiatric diseases in children in the light of the modern folate-centric scientific concept of the pathways of cerebral damage in immunopsychiatry. The main biochemical disorders, signs of oxidative stress, manifestations of immunodeficiency and related immune dysregulation, key immunedependent mechanisms of damage to the nervous system, such as reactivated neurotropic infections, autoimmune reactions to neurons and myelin of the CNS, immunoinflammatory reactions with hyperproduction of proinflammatory cytokines, that have pronounced neurotoxic effects, are analyzed in detail. The results of the main meta-analyses, systematic reviews, randomized controlled clinical trials testing various strategies for the treatment of autism spectrum disorders, based on the modern folate-centric concept of the immunopathogenesis of the disease, are also presented, in particular – diet therapy, biochemical correction, pre/probiotics and transplantation of the gut microbiome, normal i/v human immunoglobulin in high dose, infliximab and rituximab. At the end of the article, the most promising directions of further scientific research in the field of Neuroimmunology of severe neuropsychiatric syndromes in children are outlined, which can lead to revolutionary changes in the approaches to the diagnosis and treatment of previously incurable mental illnesses of the younger generation.

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Published
2023-01-09
How to Cite
Мальцев, Д., & Коляденко, Н. (2023). IMMUNOGENETIC ASPECTS OF DISEASE PATHOGENESIS IN CHILDREN WITH AUTISM SPECTRUM DISORDERS. Men’s Health, Gender and Psychosomatic Medicine, (1-2(14-15), 47-60. https://doi.org/10.37321/UJMH.2022.1-2-05