REGULARITIES OF MORPHOLOGICAL CHANGES IN THE ORGANS OF THE MALE URINARY AND GENITAL SYSTEM IN CASE OF CRYPTOSPORIDIOSIS (generalized research materials)

  • Валерій Мінухін Doctor of Medicine, Professor, Director of the Institute of Microbiology and Immunology named after І.І. Mechnikov National Academy of Medical Sciences of Ukraine»
  • Інна Торяник Candidate of Medical Sciences, Senior Research Fellow Laboratory of Viral Infections SI «Institute of Microbiology and Immunology named after І.І. Mechnikov of National Academy of Medical Sciences of Ukraine «; Kharkiv National Medical University
  • Діана Мінухіна Candidate of Medical Sciences, Assistant of the Department of Internal Medicine №1 of Kharkiv Medical University of the Ministry of Health of Ukraine
  • Сергій Похил Doctor of Medicine, Senior Research Fellow, Head of the Laboratory of New and Little-Studied Infectious Diseases of the «Institute of Microbiology and Immunology named after І.І. Mechnikov of National Academy of Medical Sciences of Ukraine»
  • Дмитро Мінухін Candidate of Medical Sciences, Associate Professor of the Department of Surgical Diseases №1 Kharkiv Medical University of the Ministry of Health of Ukraine
  • Олег Труфанов Candidate of Biological sciences, Ph.D., Associate Professor of Biochemistry, Kharkiv National University named after V.N. Karazin
  • Світлана Калітіна junior researcher of Laboratory of Biochemistry of Microorganisms SI “Institute of Microbiology and Immunology named after І.І. Mechnikov of National Academy of Medical Sciences of Ukraine»
Keywords: organs of the male genitourinary system, anomalies, sexually transmitted infections, morphological changes, cryptosporidiosis

Abstract

The aim of the study was to investigate the structural and functional changes in the male genitourinary system in the development of cryptosporidiosis.
Material and methods. The study was based on biopsies and necropsies, based on histological methods.
Results. The article is devoted to the study of structural and functional changes in the male genitourinary system in the development of cryptosporidiosis. The authors of the study emphasize the features of the nomenclature profile of cryptosporidiosis, its low certainty, the place among modern protozoal infections. The paper draws attention to the emergence of the disease, the specifics of its clinical course, the characteristics of the most accessible and effective methodological (histological) algorithm. The publication presents data on structural and functional changes of the urethra, testicles, kidneys of children with cryptosporidiosis (proven participation of the inflammatory component, destructive processes, trophic disorders). Researchers have focused on the peculiarities of the structure of the mucous membranes of the genitourinary organs in terms of cryptosporidiosis, destruction of the epithelium, microcirculation disorders. It is assumed that the factors of influence / strengthening of the latter were the activation of lysosomal (hydrolytic) enzymes capable of cleaving lipid - protein complexes of membranes.
As a result, the opinion is expressed about the role of cryptosporidiosis in the development of male infertility.
Conclusions. In the case of cryptosporidiosis, the most vulnerable structures of the male genitourinary system are cells of mesenchymal origin (epithelium).
They are characterized by atrophy, desquamation, destructive-degenerative changes, necrosis. The destruction of the endothelial layer of microvessels leads to defects in the layers of the walls of the latter, thrombosis, the development of stasis, impaired microcirculation and trophism

References

1. Варфоломєєва, Ю. В. Досвід діагностики криптоспоридіозу у ВІЛ-інфікованих хворих / Ю. В. Варфоломієва, Т. І. Трюханова, В. В. Овсяннікова, В. В. Терещенко. - Режим доступу : http://www.rusnauka.com/ 4_NIC_2016 /Medecine/ 12_207273.doc.htm
2. Глобальное бремя болезней (Global Burden of Disease): порождение доказательств направление политики ‑ региональное издание для Европы и Центральной Азии [Електронний ресурс] / Seattle, WA: IHME. ‑ 2013 ‑ Режим доступу: http://www.healthdata.org/sites/default/files/files/policy_report/2013/ WB uropeCentralAsia/IHME_GBD_WorldBank_EuropeCentralAsia_FullReport_RUSSIAN.pdf
3. Поширення криптоспоридіозу тварин в Україні / В. В. Журенко, Н. М. Сорока // Науковий вісник Національного університету біоресурсів і природокористування України. - К., 2012. - Вип. 172: Серія «Ветеринарна медицина, якість і безпека продукції тваринництва», ч. 4. - С. 22-25.
4. Торяник І.І. Вторинні ознаки криптоспоридіозу у клініко-морфологічній характеристиці гострих ентероколітів у дітей/ І.І. Торяник, Н.А. Чигиринська, І.А. Костиря / Матеріали ІV Всеукраїнської наукової конференції студентів та молодих вчених з фізіології з міжнародною участю, Харків. – 2017.- С. 135-136.
5. Checkley, W. A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium [Electronic resource] / W. Checkley, A.C. White, D. Jaganath [et al.] / The Lancet Infectious Diseases. -2014. - September, 30. - P. 1-20. - Mood of access: http://www.thelancet.com/pdfs/journals/laninf/PIIS1473-3099(14)70772-8.pdf
6. Cryptosporidiosis. Laboratory Identification of Public Health Concern (DPDx) / CDC. - 2015. – 5 p. Mode of access : http:// cdc.gov/dpdx/cryptosporidiosis/dx.html
7. Ignatius, R. Highly specific detection of Cryptosporidium spp. oocysts in human stool samples by undemanding and inexpensive phase contrast microscopy / R. Ignatius, T. Klemm, S. Zander S. [et al.] // Parasitol. Res. – 2016. -Vol. 115, No 3. – P. 1229-1234.
8. Lawley T. D. Сolonization resistance [Electronic resource] / T. D. Lawley, A. W. Walker // Immunology. ‑ 2013. – Vol. 138(1) – P. 1‑11. – Mode of access: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2012.03616. x/full
9. Painter, J. E. Cryptosporidiosis Surveillance - United States, 2011–2012 [Text] / J. E. Painter, M. C. Hlavsa, S. A. Collier, L. Xiao [et al.] // Zoon. Inf. – 2015. - Vol. 64, No. 3. - P. 15 – 25.
10. Putignani, L. Global Distribution, Public Health and Clinical Impact of the Protozoan Pathogen Cryptosporidium [Text] / L. Putignani, D. Menichella // Interdisciplinary Perspectives on Inf. Diseases. – 2010. – Vol. 2010, No. 7. - P. 1 – 39.
11. WHO: The top 10 causes of death [Electronic resource] / Fact sheet. Updated January 2017. – Mode of access: http://www.who.int/mediacentre/factsheets/fs310/en/
Published
2020-12-30
How to Cite
Мінухін, В., Торяник, І., Мінухіна, Д., Похил, С., Мінухін, Д., Труфанов, О., & Калітіна, С. (2020). REGULARITIES OF MORPHOLOGICAL CHANGES IN THE ORGANS OF THE MALE URINARY AND GENITAL SYSTEM IN CASE OF CRYPTOSPORIDIOSIS (generalized research materials). Men’s Health, Gender and Psychosomatic Medicine, (1-2), 116-123. https://doi.org/10.37321/UJMH.2020.1-2-13