• Юрий Заседа MD, Urologyst, Andrologyst, PhD, Doctor of Science, CMO of Men’s Health Clinic, Kiev
Keywords: platelet-rich plasma, low-intensity shock wave therapy, icariin, peyronie’s disease


Relevance. The spectrum of combined mechanisms of action of PRP-therapy, LISWT and LNP therapy suggests the clinical eff ect for patients with fi broplastic penile induration, which currently does not have conservative therapies that have suffi cient effi cacy.
The aim of the study was to determine the effi cacy of combined PRP-therapy with intracavernous activation of growth factors by LISWT method + LNP and ICA pharmacotherapy in treatment of fi broplastic penile induction.
Design. The study group comprised 23 patients of the Men’s Health Clinic in Kyiv, suff ering from fi broplastic penile inducing (Peyronie’s disease, ICD-10: N48.6) with erectile dysfunction.
Results of the study. A 6-month follow-up observation showed a reduction of pain during erection, a signifi cant improvement in erectile function, a total regression of the areas less than 25 mm2 and a signifi cant decrease in the density and area of the induration areas that over 25 mm2. Conclusions. It has been established that the therapeutic model of the combined use of PRP-therapy with intracavernous activation of growth factors by LISWT method + LOD + ICA in the treatment of fi broplastic penile induration, shows a pronounced clinical eff ect, which makes this therapeutic model a promising option for conservative correction of pain and erectile dysfunction in fi broplastic penile induration.


Аксьонов П.В., Романюк М.Г., Мироненко В.І. Ударно-хвильова те-рапія у лікуванні еректильної дисфункції / Здоровье мужчины. – 2017. – №4 (63) – 64-70.

Горпинченко И.И. Современное лечение эректильной дисфункции. Использование ингибиторов фосфодиэстеразы 5-го поколения / Горпинченко И.И. // Здоровье мужчины. – 2013. – № 3 (46). – С. 87–90.

Горпинченко І.І. Еректильна дисфункція та пов’язана зі здоров’ям якість життя / І.І. Горпинченко, Д.З. Воробець, П.Л.Свердан // Здоровье мужчины. – 2010. – №1 (32). – С. 54-60.

Чалый М.Е., Вилькин Я.Ф., Епифанова М.В. Способ лечения эректильной дисфункции. – Патент на изобретение РФ No 2514639. Москва. 5 марта – 2014. // Бюллетень № 12 от 27.04.2014.

Clinical effi cacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies. J Urol. 2013;190:199–207.

Eric Chung Peyronie’s disease and low intensity shock wave therapy: Clinical outcomes and patient satisfaction rate in an open-label single arm prospective study in Australian menKorean J Urol. 2015 Nov; 56(11): 775–780

Gigante A, Del Torto M, Manzotti S, Cianforlini M, Busilacchi A, Davidson PA, et al. Platelet rich fi brin matrix eff ects on skeletal muscle lesions: an experimental study. J Biol Regul Homeost Agents. 2012;26:475–484.

Kushida S, Kakudo N, Morimoto N, Hara T, Ogawa T, Mitsui T, et al. Platelet and growth factor concentrations in activated platelet-rich plasma: a comparison of seven commercial separation systems. J Artif Organs. 2014;17:186–192.

Li J, Shi Q, Pu C, Tang Y, Bai Y, Yuan H, et al. Phosphodiesterase type 5 inhibitors for the treatment of post-nerve sparing radical prostatectomy erectile dysfunction in men. Sci Rep. 2014;4:5801.

Wu CC, Wu YN, Ho HO, Chen KC, Sheu MT, Chiang HS. The neuroprotective eff ect of platelet-rich plasma on erectile function in bilateral cavernous nerve injury rat model. J Sex Med. 2012;9:2838–2848.

Wu YN, Wu CC, Sheu MT, Chen KC, Ho HO, Chiang HS. Optimization of platelet-rich plasma and its eff ects on the recovery

How to Cite
Заседа, Ю. (2019). EXPERIENCE OF COMBINING PLATELET-RICH AUTOPLASM THERAPY AND LOW-INTENSITY SHOCK-WAVE THERAPY IN TREATMENT OF PEYRONIE’S DISEASE. Men’s Health, Gender and Psychosomatic Medicine, (2), 12-18. https://doi.org/10.37321/UJMH.2018.02-01

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